The interaction between nitrous oxide and cobalamin. Biochemical effects and clinical consequences.
نویسندگان
چکیده
منابع مشابه
Megaloblastic anaemia, cobalamin, and folate.
Developments relating to cobalamin and folate are reviewed. Current work on the relations between these two coenzymes are discussed, particularly those that have emerged in studies using nitrous oxide, which inactivates cobalamin.
متن کاملCobalamin neuropathy. Is S-adenosylhomocysteine toxicity a factor?
Cobalamin neuropathy was produced in cape fruit bats (Rousettus aegyptiacus) by a cobalamin-free diet combined with intermittent exposure to nitrous oxide, which inactivates cobalamin. There were no significant differences in S-adenosylmethionine/S-adenosylhomocysteine ratios in the central nervous system of cobalamin-deficient and cobalamin-replete bats. Taken with other data there are no grou...
متن کاملMethylmalonic acid metabolism and nervous-system fatty acids in cobalamin-deficient fruit bats receiving supplements of methionine, valine and isoleucine.
Cobalamin neuropathy was produced in Cape fruit bats (Rousettus aegyptiacus) by a cobalamin-free diet combined with intermittent exposure to nitrous oxide, which inactivates cobalamin. Cobalamin-deficient bats had low hepatic methylmalonyl-CoA mutase holoenzyme activity, with elevated plasma and urinary methylmalonic acid levels. No significant changes could be demonstrated in the concentration...
متن کاملP110: Nitrous Oxide and Neuroinflammation
Nitrous oxide was an anaesthetic gas that was used for many years. There were many anaesthetic drugs in operations with many side effects. Nitrous oxide had some side effects too. But it was a safe gas in many times. In hospital personnel who worked in operating rooms exposure to this gas was important. The objective of this study was the introduction of nitrous oxide and neurologic side ...
متن کاملAltered vitamin B12 metabolism in fibroblasts from a patient with megaloblastic anemia and homocystinuria due to a new defect in methionine biosynthesis.
Cultured fibroblasts from a recently described patient with homocystinuria and megaloblastic anemia of infancy without methylmalonic aciduria were previously shown to have normal cobalamin uptake and a specific decrease in the proportion of intracellular methylcobalamin. As in control cells but unlike in those from patients with combined homocystinuria and methylmalonic aciduria (cobalamin C an...
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عنوان ژورنال:
- Acta anaesthesiologica Scandinavica
دوره 38 8 شماره
صفحات -
تاریخ انتشار 1994